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华大时空组学技术Stereo-seq已被成功应用到器官发生、胚胎发育、生命演化、脑科学、肿瘤等多个不同领域,证明了其普适性。未来,时空组学有望应用到生命科学与临床研究的各个领域,尤其疾病研究领域,最终为人类健康带来极大的改善。目前,已有150余篇Stereo-seq及其应用成果发表在CellNatureScience等国际顶级学术期刊。

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Spatiotemporal transcriptomic maps of mouse intracerebral hemorrhage at single-cell resolution

2025-05-23 DOI: 10.1016/j.neuron.2025.04.026

Spatiotemporal transcriptomic maps of mouse intracerebral hemorrhage at single-cell resolution

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期刊·Neuron 物种·小鼠 样本类型·脑出血后小鼠大脑样本
Spatial multiomics decipher fibroblast–macrophage dynamics in systemic sclerosis

2025-05-22 DOI:10.1016/j.ard.2025.04.025

Spatial multiomics decipher fibroblast–macrophage dynamics in systemic sclerosis

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期刊·Annals of the Rheumatic Diseases 物种·人 样本类型·例弥漫型皮肤系统性硬化症(SSc)患者样本
Integrating Spatial and Single-Nucleus Transcriptomic Data to Assess the Effects of Intrauterine Hyperglycemia on Fetal Pancreatic Development

2025-05-19 DOI:10.1002/advs.202411126

Integrating Spatial and Single-Nucleus Transcriptomic Data to Assess the Effects of Intrauterine Hyperglycemia on Fetal Pancreatic Development

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期刊·Advanced Science 物种·母体孕前糖尿病条件下胎儿 样本类型·胰腺
Adv. Sci | 从“奋斗”到“躺平”?Stereo-seq助力揭示肝脏应对“虫癌”的免疫应答机制

2025-05-15 DOI:10.1002/advs.202405914

Adv. Sci | 从“奋斗”到“躺平”?Stereo-seq助力揭示肝脏应对“虫癌”的免疫应答机制

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期刊·Advanced science 物种·小鼠 样本类型·肝脏
Single-cell spatial transcriptomics of tertiary lymphoid organ-like structures in human atherosclerotic plaques

2025-04-28 DOI:10.1038/s44161-025-00639-9

Single-cell spatial transcriptomics of tertiary lymphoid organ-like structures in human atherosclerotic plaques

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期刊·Nature Cardiovascular Research 物种·小鼠及人 样本类型·淋巴器官
Nature子刊 | 首次揭示人类颈动脉斑块中三级淋巴器官!Stereo-seq新突破

2025-04-28 DOI:10.1038/s44161-025-00639-9

Nature子刊 | 首次揭示人类颈动脉斑块中三级淋巴器官!Stereo-seq新突破

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期刊·Nature cardiovascular research 物种·人 样本类型·颈动脉粥样硬化斑块中三级淋巴器官
Single-nucleus RNA sequencing and spatial transcriptomics reveal the mechanism by which Xiaozhiling injection treats internal hemorrhoids

2025-04-27 DOI:10.4240/wjgs.v17.i4.103494

Single-nucleus RNA sequencing and spatial transcriptomics reveal the mechanism by which Xiaozhiling injection treats internal hemorrhoids

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期刊·World J Gastrointest Surg 物种·大鼠 样本类型·肛肠
Spatially resolved atlas of breast cancer uncovers intercellular machinery of venular niche governing lymphocyte extravasation

2025-04-09 DOI:10.1038/s41467-025-58511-0

Spatially resolved atlas of breast cancer uncovers intercellular machinery of venular niche governing lymphocyte extravasation

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期刊·Nature Communications 物种·人 样本类型·乳腺
Cancer Cell | Stereo-seq助力首次绘制肝细胞癌中TLS的全景发育图谱

2025-04-03 DOI: 10.1016/j.ccell.2025.03.011

Cancer Cell | Stereo-seq助力首次绘制肝细胞癌中TLS的全景发育图谱

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期刊·Cancer Cell 物种·人 样本类型·肝脏
Nature | 首次绘制出人类复杂疾病相关的大脑细胞“空间地图”

2025-03-19 DOI:10.1038/s41586-025-08757-x

Nature | 首次绘制出人类复杂疾病相关的大脑细胞“空间地图”

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期刊·Nature 物种·小鼠、猴子 样本类型·小鼠胚胎、猴子大脑